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What is PROVIGIL, and what does it do?
PROVIGIL is a medication to treat excessive sleepiness caused by certain
sleep disorders. These sleep disorders are obstructive sleep apnea/hypopnea
syndrome (OSAHS), narcolepsy, and shift work sleep disorder (SWSD).
Buy Provigil (Modafinil) Online
Modafinil ('Provigil', 'Alertec', 'Vigicer', 'Modalert', etc) is a
memory-improving and mood-brightening psychostimulant. It enhances
wakefulness and vigilance, but its pharmacological profile is notably
different from the amphetamines, methylphenidate (Ritalin) or cocaine.
Modafinil is less likely to cause jitteriness, anxiety, or excess
locomotor activity - or lead to a hypersomnolent 'rebound effect' - than
traditional stimulants. Subjectively, it feels smoother and cleaner than
the amphetamines too. It may even be anxiolytic. The normal elimination
half-life of modafinil in humans is between 12 - 15 hours. So it's worth
fine-tuning one's dosage schedule accordingly.
Current
research suggests modafinil, like its older and better-tested analogue
adrafinil, is a safe, effective and well-tolerated agent. It is
long-acting and doesn't tend to cause peripheral sympathetic
stimulation. Yet its CNS action isn't fully understood. Modafinil
induces wakefulness in part by its action in the anterior hypothalamus.
Its dopamine-releasing action in the nucleus accumbens is weak and
dose-dependent; the likelihood of a euphoric response ('abuse
potential'), dose-escalation and tolerance is thus apparently small.
Modafinil has central alpha 1-adrenergic agonist effects i.e. it
directly stimulates the receptors. Modafinil inhibits the reuptake of
noradrenaline by the noradrenergic terminals on sleep-promoting neurons
of ventrolateral preoptic nucleus (VLPO). More significant, perhaps, is
its ability to increase excitatory glutamatergic transmission. This
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receptor signalling on the mesolimbic dopamine terminals.
Cephalon, Takeda To Co-Promote Provigil In US
06-12-06 05:26 PM EST
DOW JONES NEWSWIRES
Cephalon Inc. (CEPH) and Takeda Pharmaceutical North America Inc. will
co- promote Provigil in the U.S.
In July, 500 Takeda sales representatives will begin promoting Provigil,
which is indicated for improving wakefulness. At that time, the Cephalon
and Takeda sales force promoting Provigil will comprise 900 people.
The co-promotion agreement will run for three years with an option to
renew annually. Cephalon, of Frazer, Pa., will retain all responsibility
for the development of Provigil, and pay Takeda a royalty.
Takeda Pharmaceuticals North America, of Liconlnshire, Ill., is a unit
of Takeda Pharmaceutical Co. (4502.TO) of Japan.
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Are You Tired?
Do you feel tired even when you have had enough sleep? Do you often feel
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Everyone gets sleepy from time to time, but if sleepiness is keeping you
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of several sleep disorders such as narcolepsy, OSA and SWSD. If you
think you may have excessive sleepiness, talk to your doctor.
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