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What is PROVIGIL, and what does it do?
PROVIGIL is a medication to treat excessive sleepiness caused by certain sleep disorders. These sleep disorders are obstructive sleep apnea/hypopnea syndrome (OSAHS), narcolepsy, and shift work sleep disorder (SWSD).

Buy Provigil (Modafinil) Online
Modafinil ('Provigil', 'Alertec', 'Vigicer', 'Modalert', etc) is a memory-improving and mood-brightening psychostimulant. It enhances wakefulness and vigilance, but its pharmacological profile is notably different from the amphetamines, methylphenidate (Ritalin) or cocaine. Modafinil is less likely to cause jitteriness, anxiety, or excess locomotor activity - or lead to a hypersomnolent 'rebound effect' - than traditional stimulants. Subjectively, it feels smoother and cleaner than the amphetamines too. It may even be anxiolytic. The normal elimination half-life of modafinil in humans is between 12 - 15 hours. So it's worth fine-tuning one's dosage schedule accordingly.

buy discount provigil onlineCurrent research suggests modafinil, like its older and better-tested analogue adrafinil, is a safe, effective and well-tolerated agent. It is long-acting and doesn't tend to cause peripheral sympathetic stimulation. Yet its CNS action isn't fully understood. Modafinil induces wakefulness in part by its action in the anterior hypothalamus. Its dopamine-releasing action in the nucleus accumbens is weak and dose-dependent; the likelihood of a euphoric response ('abuse potential'), dose-escalation and tolerance is thus apparently small. Modafinil has central alpha 1-adrenergic agonist effects i.e. it directly stimulates the receptors. Modafinil inhibits the reuptake of noradrenaline by the noradrenergic terminals on sleep-promoting neurons of ventrolateral preoptic nucleus (VLPO). More significant, perhaps, is its ability to increase excitatory glutamatergic transmission. This reduces local GABAergic transmission, thereby diminishing GABA(A) receptor signalling on the mesolimbic dopamine terminals.


Cephalon, Takeda To Co-Promote Provigil In US

06-12-06 05:26 PM EST
DOW JONES NEWSWIRES

Cephalon Inc. (CEPH) and Takeda Pharmaceutical North America Inc. will co- promote Provigil in the U.S.

In July, 500 Takeda sales representatives will begin promoting Provigil, which is indicated for improving wakefulness. At that time, the Cephalon and Takeda sales force promoting Provigil will comprise 900 people.

The co-promotion agreement will run for three years with an option to renew annually. Cephalon, of Frazer, Pa., will retain all responsibility for the development of Provigil, and pay Takeda a royalty.

Takeda Pharmaceuticals North America, of Liconlnshire, Ill., is a unit of Takeda Pharmaceutical Co. (4502.TO) of Japan.

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Are You Tired?
Do you feel tired even when you have had enough sleep? Do you often feel like you just don’t have the energy to do the things you need to do?

Everyone gets sleepy from time to time, but if sleepiness is keeping you from doing the things you need to do on a daily basis, you may be suffering from excessive sleepiness, a common and often serious symptom of several sleep disorders such as narcolepsy, OSA and SWSD. If you think you may have excessive sleepiness, talk to your doctor.
 

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