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The following information is a summary about XENICAL. It is not intended to replace a doctor's instructions.

(ORLISTAT - ORAL)

USES
XENICAL is a prescription weight-control medication useful for the long-term treatment of significant obesity.

XENICAL can also help to reduce risk factors, such as high blood pressure, high cholesterol and high blood sugar which, if not treated, could lead to other diseases such as hypertension and diabetes. Each XENICAL capsule contains 120 mg of the active substance orlistat, which acts as a lipase inhibitor.

XENICAL is a weight loss medication that targets the absorption of fat in your body rather than suppressing your appetite. It is useful for long term use and has been shown to be effective for 1-2 years. Dietary fats are inhibited from being absorbed and this allows about 30% of the fat eaten in the mealb to pass through the gut undigested. This helps you to reduce and maintain your weight, as well as to minimize any weight regain.

PRECAUTIONS
This medicine can cause changes in your bowel habits, such as fatty or oily stools, due to the elimination of undigested fat in your stool. XENICAL reduces the absorption of supplements of some fat soluble nutrients, particularly beta-carotene and vitamin E. You should therefore follow your doctor's advice in taking a well balanced diet rich in fruit and vegetables. XENICAL should not be used if you have an allergy to it or suffer from chronic malabsorption syndromes such as sprue or steatorrhea. It is also not intended for use with children or pregnant or nursing women.

DIRECTIONS
XENICAL is taken with each meal (three times daily). Your daily fat intake should be divided equally between these three meals so you will benefit from XENICAL's actions. Your medicine should be swallowed with water.

SIDE EFFECTS
Side effects include loose stools and increased gas or flatulence. These symptoms are generally mild, occur at the beginning of treatment, go away after a short period of time and are usually experienced after meals containing high levels of fat. Normally, these symptoms disappear if you continue treatment and keep to your recommended diet.

Xenical Can Assist Weight Loss
The importance of long-term weight management to achieve significant weight loss and improvement to associated health risks such as coronary heart disease has been reinforced by a new study of Xenical, the lipase inhibitor that limits fat absorption in the digestive tract.

Steady Weight Loss and Waist reduction
The results of the study show that the obesity medication Xenical (orlistat) assists patients to maintain steady weight loss and lose up to 10.8cm from their waist if the weight management plan is maintained for a year. Excess fat around the waist is associated with insulin resistance - a known risk factor for type 2 diabetes, high cholesterol levels and high blood pressure. (Waist measurements over 102cms for men and 88cms for women can cause serious health complications.)

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